E8 - How to use & avoid light to optimize health with Samer Hattar - Show notes Link to Samer’s episode on the Hubermanlab Podcast: Dr. Samer Hattar: Timing Light, Food, & Exercise for Better Sleep, Energy & Mood | Huberman Lab #43 https://www.youtube.com/watch?v=oUu3f0ETMJQ Papers that Samer and I refer to: Part 2: Extraocular Circadian Phototransduction in Humans (Campbell & Murphy 1998) https://www.science.org/doi/10.1126/science.279.5349.396?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed Absence of Circadian Phase Resetting in Response to Bright Light Behind the Knees (Wright & Czeisler 2002) https://www.science.org/doi/full/10.1126/science.1071697 FAILURE OF EXTRAOCULAR LIGHT TO FACILITATE CIRCADIAN RHYTHM REENTRAINMENT IN HUMANS (Eastman et al. 2000) https://www.tandfonline.com/doi/abs/10.1081/cbi-100102116?journalCode=icbi20 Regulation of Mammalian Circadian Behavior by Non-rod, Non-cone, Ocular Photoreceptors (Freedman et al. 1999) https://www.science.org/doi/full/10.1126/science.284.5413.502 Neuropsin (OPN5)-mediated photoentrainment of local circadian oscillators in mammalian retina and cornea (Buhr et al. 2015) https://www.pnas.org/doi/abs/10.1073/pnas.1516259112 Opsins have also been found in adipocytes of humans and mice: Subcutaneous white adipocytes express a light sensitive signaling pathway mediated via a melanopsin/TRPC channel axis (Ondrusova et al. 2017) https://pubmed.ncbi.nlm.nih.gov/29180820/ Adaptive Thermogenesis in Mice Is Enhanced by Opsin 3-Dependent Adipocyte Light Sensing (Nayak et al. 2020) https://pubmed.ncbi.nlm.nih.gov/31968245/ Differential effects of light and feeding on circadian organization of peripheral clocks in a forebrain Bmal1 mutant (Izumo et al. 2014) https://elifesciences.org/articles/04617 Retinal innervation tunes circuits that drive nonphotic entrainment to food (Fernandez et al. 2020) https://www.nature.com/articles/s41586-020-2204-1 Metabolic consequences of sleep and sleep loss (van Cauter et al. 2008) https://www.sciencedirect.com/science/article/pii/S1389945708700133 Relationship between Sleep and Hedonic Appetite in Shift Workers (Vidafar et al. 2020) https://www.mdpi.com/2072-6643/12/9/2835 Increased Hunger, Food Cravings, Food Reward, and Portion Size Selection after Sleep Curtailment in Women Without Obesity (Yang et al. 2019) https://www.mdpi.com/2072-6643/11/3/663 NIH researcher studying sleep deprivation: Kong Chen https://www.niddk.nih.gov/about-niddk/staff-directory/biography/chen-kong Moonstruck sleep: Synchronization of human sleep with the moon cycle under field conditions (Casiraghi et al. 2021) https://www.science.org/doi/full/10.1126/sciadv.abe0465 A Circannual Clock Drives Expression of Genes Central for Seasonal Reproduction (de Miera et al. 2014) https://www.sciencedirect.com/science/article/pii/S0960982214005491 Light can activate the human prefrontal cortex: Luxotonic signals in human prefrontal cortex as a possible substrate for effects of light on mood and cognition (Sabbah et al. 2022) https://www.pnas.org/doi/10.1073/pnas.2118192119 Samer Hattar on Social Media: Twitter: @SamerHattar NIH-Homepage: https://www.nimh.nih.gov/research/research-conducted-at-nimh/principal-investigators/samer-hattar