E13 - Health risks of shift work and how to minimize them with Frank Scheer - Show notes

Part 1:

Correction by Frank Scheer:
"The Medical Chronobiology Program was already founded in 2005, not 2015."

Main papers:
Daytime eating prevents internal circadian misalignment and glucose intolerance in night work (Chellappa et al. 2021)
	https://www.science.org/doi/10.1126/sciadv.abg9910

Late isocaloric eating increases hunger, decreases energy expenditure, and modifies metabolic pathways in adults with overweight and obesity (Vujovic et al. 2022)	
	https://www.cell.com/cell-metabolism/pdfExtended/S1550-4131(22)00397-7


Additional papers that Frank and I refer to:

Adaptation of the circadian rhythm of 6-sulphatoxymelatonin to a shift schedule of seven nights followed by seven days in offshore oil installation workers (Gibbs et al. 2002)
	https://doi.org/10.1016/S0304-3940(02)00247-1

Adaptation of the melatonin rhythm in human subjects following night-shift work in Antarctica (Midwinter & Arendt 1991)
	https://pubmed.ncbi.nlm.nih.gov/2027519/

Energy Expenditure and Changes in Body Composition During Submarine Deployment—An Observational Study “DasBoost 2-2017” (Rietjens et al. 2020)
	https://www.mdpi.com/2072-6643/12/1/226

The Relationship between Working Night Shifts and Depression among Nurses: A Systematic Review and Meta-Analysis (Okechukwu et al. 2023)
	https://pubmed.ncbi.nlm.nih.gov/37046864/

Circadian misalignment increases mood vulnerability in simulated shift work (Chellappa et al. 2020)
	https://www.nature.com/articles/s41598-020-75245-9

TProof-of-principle demonstration of endogenous circadian system and circadian misalignment effects on human oral microbiota (Chellappa et al. 2022)
	https://pubmed.ncbi.nlm.nih.gov/34861073/

Review articles on shift work and health risks:
Impact of circadian disruption on glucose metabolism: implications for type 2 diabetes (Mason et al. 2020) 
	https://pubmed.ncbi.nlm.nih.gov/31915891/
Impact of Circadian Disruption on Cardiovascular Function and Disease (Chellappa et al. 2019)
	https://pubmed.ncbi.nlm.nih.gov/31427142/
Health consequences of circadian disruption (Sletten et al. 2020)
	https://academic.oup.com/sleep/article/43/1/zsz194/5699236?login=true

Effects of circadian disruption on the cardiometabolic system (Rüger & Scheer 2009)
	https://link.springer.com/article/10.1007/s11154-009-9122-8

The endogenous circadian system worsens asthma at night independent of sleep and other daily behavioral or environmental cycles (Scheer et al. 2020)
	https://www.pnas.org/doi/abs/10.1073/pnas.2018486118

The two-process model of sleep regulation: Beginnings and outlook (Borbely 2022)
	https://onlinelibrary.wiley.com/doi/full/10.1111/jsr.13598

Controlling for sleep as a factor in the negative effects of shift work, circadian misalignment is above and beyond sleep-disruptive effects:
Circadian Misalignment Augments Markers of Insulin Resistance and Inflammation, Independently of Sleep Loss (Leproult et al. 2014)
	https://diabetesjournals.org/diabetes/article/63/6/1860/34298/Circadian-Misalignment-Augments-Markers-of-Insulin

Endogenous circadian system and circadian misalignment impact glucose tolerance via separate mechanisms in humans (Morris et al. 2015)
	https://www.pnas.org/doi/abs/10.1073/pnas.1418955112

Adverse metabolic and cardiovascular consequences of circadian misalignment (Scheer et al. 2009)
	https://www.pnas.org/doi/abs/10.1073/pnas.0808180106

Shift work studies in mice by Carolina Escobar
Food Intake during the Normal Activity Phase Prevents Obesity and Circadian Desynchrony in a Rat Model of Night Work (Salgado-Delgado et al. 2010)
	https://academic.oup.com/endo/article/151/3/1019/2456529
Shift Work or Food Intake during the Rest Phase Promotes Metabolic Disruption and Desynchrony of Liver Genes in Male Rats (Salgado-Delgado et al. 2013)
	https://doi.org/10.1371/journal.pone.0060052

Timing of food intake predicts weight loss effectiveness (Garaulet et al. 2013)
	https://www.nature.com/articles/ijo2012229


How to contact Frank Scheer:
LinkedIn: https://www.linkedin.com/in/frankscheer/
Email: FSCHEER@BWH.HARVARD.EDU