E5 - Timing of exercise and why it can matter with Saar Ezagouri - Show notes


Main paper that we discuss:

Physiological and Molecular Dissection of Daily Variance in Exercise Capacity
	https://doi.org/10.1016/j.cmet.2019.03.012


Other papers that we refer to in our discussion:

Afternoon exercise is more efficacious than morning exercise at improving blood glucose levels in individuals with type 2 diabetes: a randomised crossover trial (Savikj et al. 2019)
	https://link.springer.com/article/10.1007/s00125-018-4767-z

A circadian gene expression atlas in mammals: Implications for biology and medicine (Zhang et al. 2014)
	https://doi.org/10.1073/pnas.1408886111

CRY1/2 Selectively Repress PPARδ and Limit Exercise Capacity (Jordan et al. 2017)
	https://doi.org/10.1016/j.cmet.2017.06.002

Clock proteins and training modify exercise capacity in a daytime-dependent manner (Adamovich et al. 2021)
	https://doi.org/10.1073/pnas.2101115118

PER2 controls lipid metabolism by direct regulation of PPARγ (Grimaldi et al. 2010)
	https://doi.org/10.1016/j.cmet.2010.10.005

The Circadian Protein Period2 Suppresses mTORC1 Activity via Recruiting Tsc1 to mTORC1 Complex (Wu et al. 2019)
	https://doi.org/10.1016/j.cmet.2018.11.006
	
AMPK Activation via Modulation of De Novo Purine Biosynthesis with an Inhibitor of ATIC Homodimerization (Asby et al. 2015)
	https://doi.org/10.1016/j.chembiol.2015.06.008

Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain (Horowitz et al. 2020)
	https://doi.org/10.1126/science.aaw2622

Transcriptomic, proteomic and phosphoproteomic underpinnings of daily exercise performance and zeitgeber activity of training in mouse muscle (Maier et al. 2022)
	https://doi.org/10.1113/JP281535

Atlas of exercise metabolism reveals time-dependent signatures of metabolic homeostasis (Kräuchi et al. 1999)
	https://doi.org/10.1016/j.cmet.2021.12.016

Saar's and Gad Asher's review on circadian control in mitochondria:
Circadian control of mitochondrial dynamics and functions (Ezagouri & Asher 2018)
	https://doi.org/10.1016/j.cophys.2018.05.008

References to the marathon mice (Ronald Evans):
	https://www.hhmi.org/news/researchers-identify-drugs-enhance-exercise-endurance

	https://www.cell.com/fulltext/S0092-8674(08)00838-6


Saar Ezagourio on Social Media:
Twitter: @SaarEzagouri_RD
Email: saare@weizmann.ac.il